The Longevity Acceleration Roadmap

A Technical Plan to Solve Aging

V1 Outline

Video | Podcast

We need a plan.

Ending aging and death is humanity's greatest challenge. Yet we lack a coherent technical plan to solve it. This is the biggest obstacle to effectively attracting and allocating talent and resources in longevity.

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Assets for Webflow builders.

Focus only on critical research and technology paths that could plausibly solve aging completely.

Map key technical objectives in a logical sequential narrative without gaps.

Include estimates for time and cost to derisk specific roadmap objectives.

Lists the companies and organizations working on the roadmap objectives, to guide new talent and funders.  
The LBF Roadmap project seeks to estimate both time and cost estimates to achieve key technical objectives.

Three paths

Critical path technology paths to extend lifespan indefinitely, in order of greatest potential impact relative to current funding of pathway.  

01/ Replacement

Replace old parts with young. Full body transplants + gradual brain replacement.


02/ Biostasis

Pausing biological activity and deterioation indefinitely with reversible cryopreservation and/or chemical fixation.


03/ Bioengineering

Vastly more advanced computational models of biology plus genetic and cellular engineering tools.


Roadmap V1 Outline

An overview of the roadmap we are building including: our rationale for building it, inclusion criteria, technical objectives, key recent science, existing and proposed projects, and our process for updating and filling in details through expert interviews and community engagement. The full roadmap will include actionable information on how to start, join, or support key projects.


Presented at VitaDAO Life Extension Conference, Vitalia (Feb 24th, 2024)


We're doing deep dive interviews with experts to understand their mental models and pathways to solve aging -- and updating the roadmap.

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Frequently Asked Questions

Please read before throwing stones.

Do we really need a plan to solve aging?

Yes. Solving aging is one of the most challenging and meaningful technological achievements humanity will ever undertake.

Could you imagine trying to map the human genome, land on the moon, or build a fusion reactor for the first time without some overarching plan?

What about aging pharma or "low hanging fruit"?  

Despite most funding in longevity biotech going towards traditional pharma approaches, this strategy will likely have modest lifespan effect sizes and are not a scalable solution to address all potential mechanisms and processes of aging.

This doesn't mean that aging pharma isn't a worthwhile endeavour. We certainly support these efforts, but they should not be the dominant focus.

It is often argued that initial aging pharma dugs may help drive funding and interest in longevity, but the key technologies that could actually solve aging will take longer to develop, are severely underfunded, and need to be worked on today.

What about SENS? Hallmarks of Aging?

The Strategies for Engineered Negligible Senescence (SENS) approach proposed by Aubrey de Grey in 2002 is a categorization of different possible forms of cellular or molecular damage associated with aging, with some proposed repair strategies. However, it leaves out many promising alternative approaches.  

The Hallmarks of Aging is a similar (arguably derivative) categorization system of possible aging mechanisms with no specific proposals for how to address them.

How can I get involved in the LBF Roadmap?

1. Support our work at LBF by donating here.
2. Get to work on aging by working on the key technology paths and joining the LBF Community.
3. Invest in our fund Longevity Acceleration Fund, which funds ambitious founders working on key areas of the technical roadmap.
4. Are you an expert? Give us feedback or come on our podcast to discuss the roadmap.

Are these the only paths to solve aging?

The LBF roadmap is a living document covering the most plausible strategies to solve aging based on the technologies and scientific knowledge that we possess today. This will change in the future as new unanticipated discoveries and breakthroughs are made, and we will update the plan accordingly.

Is solving aging possible in our lifetimes?

Yes, solving the problem of biological aging is plausible within the lifetimes of people alive today.

However, we are not on track to solve aging given the extremely low resource allocation.

And while the LBF roadmap describes how to attempt the development of certain life extending technologies, there are still significant scientific and technology risks to these approaches.