Longevity Bottlenecks

LBF Bottlenecks Consortium

The LBF community is dedicated to maximally accelerating progress in longevity. While the field has seen substantial advances in the past decade, there are clear and systemic deficiencies that have received little attention but retard progress for many. To coordinate efforts and identify the highest leverage intervention points, it is necessary to first understand and map these deficiencies and bring them into limelight.

We aimed to establish an empirical, systematic, rigorous, and minimally biased methodology to map bottlenecks across the field. To do so, we surveyed 400 participants across various sectors of longevity, asking them for their biggest bottlenecks and most wanted solutions in structured and free-form questions. From the more than 1000 answers, we built a classification system of Bottlenecks and Solutions and tabulated the frequency of each. The result is a first-of-a-kind taxonomy of the biggest needs and biggest wants of the longevity space.

In this site you’ll find the main takeaways of this work. For more detail, see our preprint paper, explore the answers in our interactive site, or access the full dataset for your own analysis.

Most importantly, if you want to make an impact and help solve or fund solving any of these bottlenecks, sign up to a working group below.

I. The biggest bottlenecks are:

A lack of validated aging biomarkers; a lack of funding; a lack of good aging models; and a lack of a defined regulatory path

In your work in aging, what are the biggest bottlenecks you currently face?

Figure 1. Top 15 bottlenecks, and a summary of all bottlenecks across all participants.  The area of the bubble is proportional to the number of answers.

II. Different professions have different bottlenecks

In your work in aging, what are the biggest bottlenecks you currently face?

Figure 2. Profession-specific bottlenecks.

III. The most needed solution is:

More and better access to data

If it was available, which one tool, resource, or regulatory/social/other type of change would have the biggest positive impact on your work?

Figure 3. Summary and top 15 most needed solutions across all participants.

IV. People are most optimistic about:

Reprogramming, genetic medicine, and organ replacement

For each intervention, how many years of life do you think they will add to the average lifespan of generally healthy people in 5, 10, and 25 years of research?

Figure 4. Perceived efficacy of interventions in the short-term, mid-term and long-term across all participants. Each dot represents one individual answer.

V. Most people want to live to:

100 years or indefinitely

Assuming continuous good health, how long would you want to live?

Figure 5. Personal longevity goals of participants.

Explore the Data

Visit our interactive site or access the full data and see how different members of the longevity community responded

Read the Full Paper

Check out the preprint of our paper and see what we found

Join a working group to make an impact

Now the real work begins. We are organizing working groups around these bottlenecks to build towards solutions. If you want to work with like-minded people and champion, fund, or contribute to a solution, sign up below.

We will send out invites to initial round-table discussions, organize bottleneck-specific meetups and keep you updated on overall progress.

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Meet the Team